Idiopathic hyposmia as a preclinical sign of Parkinson's disease
Identifieur interne : 001622 ( Main/Exploration ); précédent : 001621; suivant : 001623Idiopathic hyposmia as a preclinical sign of Parkinson's disease
Auteurs : Mirthe M. Ponsen [Pays-Bas] ; Diederick Stoffers [Pays-Bas] ; Jan Booij [Pays-Bas] ; Berthe L. F. Van Eck-Smit [Pays-Bas] ; Erik Ch. Wolters [Pays-Bas] ; Henk W. Berendse [Pays-Bas]Source :
- Annals of Neurology [ 0364-5134 ] ; 2004-08.
Abstract
Olfactory dysfunction is an early and common symptom in Parkinson's disease (PD). In an effort to determine whether otherwise unexplained (idiopathic) olfactory dysfunction is associated with an increased risk of developing PD, we designed a prospective study in a cohort of 361 asymptomatic relatives (parents, siblings, or children) of PD patients. A combination of olfactory detection, identification, and discrimination tasks was used to select groups of hyposmic (n = 40) and normosmic (n = 38) individuals for a 2‐year clinical follow‐up evaluation and sequential single‐photon emission computed tomography (SPECT), using [123I]β‐CIT as a dopamine transporter ligand, to assess nigrostriatal dopaminergic function at baseline and 2 years from baseline. A validated questionnaire, sensitive to the presence of parkinsonism, was used in the follow‐up of the remaining 283 relatives. Two years from baseline, 10% of the individuals with idiopathic hyposmia, who also had strongly reduced [123I]β‐CIT binding at baseline, had developed clinical PD as opposed to none of the other relatives in the cohort. In the remaining nonparkinsonian hyposmic relatives, the average rate of decline in dopamine transporter binding was significantly higher than in the normosmic relatives. These results indicate that idiopathic olfactory dysfunction is associated with an increased risk of developing PD of at least 10%. Ann Neurol 2004
Url:
DOI: 10.1002/ana.20160
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Idiopathic hyposmia as a preclinical sign of Parkinson's disease</title><author><name sortKey="Ponsen, Mirthe M" sort="Ponsen, Mirthe M" uniqKey="Ponsen M" first="Mirthe M." last="Ponsen">Mirthe M. Ponsen</name></author><author><name sortKey="Stoffers, Diederick" sort="Stoffers, Diederick" uniqKey="Stoffers D" first="Diederick" last="Stoffers">Diederick Stoffers</name></author><author><name sortKey="Booij, Jan" sort="Booij, Jan" uniqKey="Booij J" first="Jan" last="Booij">Jan Booij</name></author><author><name sortKey="Van Eck Mit, Berthe L F" sort="Van Eck Mit, Berthe L F" uniqKey="Van Eck Mit B" first="Berthe L. F." last="Van Eck-Smit">Berthe L. F. Van Eck-Smit</name></author><author><name sortKey="Wolters, Erik Ch" sort="Wolters, Erik Ch" uniqKey="Wolters E" first="Erik Ch." last="Wolters">Erik Ch. Wolters</name></author><author><name sortKey="Berendse, Henk W" sort="Berendse, Henk W" uniqKey="Berendse H" first="Henk W." last="Berendse">Henk W. Berendse</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:2CFD60A7F4B38A6BC5CE517081EBCB0B056A68EB</idno><date when="2004" year="2004">2004</date><idno type="doi">10.1002/ana.20160</idno><idno type="url">https://api.istex.fr/document/2CFD60A7F4B38A6BC5CE517081EBCB0B056A68EB/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000A71</idno><idno type="wicri:Area/Main/Curation">000935</idno><idno type="wicri:Area/Main/Exploration">001622</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Idiopathic hyposmia as a preclinical sign of Parkinson's disease</title><author><name sortKey="Ponsen, Mirthe M" sort="Ponsen, Mirthe M" uniqKey="Ponsen M" first="Mirthe M." last="Ponsen">Mirthe M. Ponsen</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Research Institute Neurosciences Vrije Universiteit, Department of Neurology, VU University Medical Center Amsterdam</wicri:regionArea><wicri:noRegion>VU University Medical Center Amsterdam</wicri:noRegion></affiliation></author><author><name sortKey="Stoffers, Diederick" sort="Stoffers, Diederick" uniqKey="Stoffers D" first="Diederick" last="Stoffers">Diederick Stoffers</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Research Institute Neurosciences Vrije Universiteit, Department of Neurology, VU University Medical Center Amsterdam</wicri:regionArea><wicri:noRegion>VU University Medical Center Amsterdam</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Neuropsychology, Vrije Universiteit, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Booij, Jan" sort="Booij, Jan" uniqKey="Booij J" first="Jan" last="Booij">Jan Booij</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Nuclear Medicine, Academic Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Van Eck Mit, Berthe L F" sort="Van Eck Mit, Berthe L F" uniqKey="Van Eck Mit B" first="Berthe L. F." last="Van Eck-Smit">Berthe L. F. Van Eck-Smit</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Nuclear Medicine, Academic Medical Center, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Wolters, Erik Ch" sort="Wolters, Erik Ch" uniqKey="Wolters E" first="Erik Ch." last="Wolters">Erik Ch. Wolters</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Research Institute Neurosciences Vrije Universiteit, Department of Neurology, VU University Medical Center Amsterdam</wicri:regionArea><wicri:noRegion>VU University Medical Center Amsterdam</wicri:noRegion></affiliation></author><author><name sortKey="Berendse, Henk W" sort="Berendse, Henk W" uniqKey="Berendse H" first="Henk W." last="Berendse">Henk W. Berendse</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Research Institute Neurosciences Vrije Universiteit, Department of Neurology, VU University Medical Center Amsterdam</wicri:regionArea><wicri:noRegion>VU University Medical Center Amsterdam</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of Neurology</title><title level="j" type="sub">Official Journal of the American Neurological Association and the Child Neurology Society</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2004-08">2004-08</date><biblScope unit="volume">56</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="173">173</biblScope><biblScope unit="page" to="181">181</biblScope></imprint><idno type="ISSN">0364-5134</idno></series><idno type="istex">2CFD60A7F4B38A6BC5CE517081EBCB0B056A68EB</idno><idno type="DOI">10.1002/ana.20160</idno><idno type="ArticleID">ANA20160</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Olfactory dysfunction is an early and common symptom in Parkinson's disease (PD). In an effort to determine whether otherwise unexplained (idiopathic) olfactory dysfunction is associated with an increased risk of developing PD, we designed a prospective study in a cohort of 361 asymptomatic relatives (parents, siblings, or children) of PD patients. A combination of olfactory detection, identification, and discrimination tasks was used to select groups of hyposmic (n = 40) and normosmic (n = 38) individuals for a 2‐year clinical follow‐up evaluation and sequential single‐photon emission computed tomography (SPECT), using [123I]β‐CIT as a dopamine transporter ligand, to assess nigrostriatal dopaminergic function at baseline and 2 years from baseline. A validated questionnaire, sensitive to the presence of parkinsonism, was used in the follow‐up of the remaining 283 relatives. Two years from baseline, 10% of the individuals with idiopathic hyposmia, who also had strongly reduced [123I]β‐CIT binding at baseline, had developed clinical PD as opposed to none of the other relatives in the cohort. In the remaining nonparkinsonian hyposmic relatives, the average rate of decline in dopamine transporter binding was significantly higher than in the normosmic relatives. These results indicate that idiopathic olfactory dysfunction is associated with an increased risk of developing PD of at least 10%. Ann Neurol 2004</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Hollande-Septentrionale</li></region><settlement><li>Amsterdam</li></settlement></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Ponsen, Mirthe M" sort="Ponsen, Mirthe M" uniqKey="Ponsen M" first="Mirthe M." last="Ponsen">Mirthe M. Ponsen</name></noRegion><name sortKey="Berendse, Henk W" sort="Berendse, Henk W" uniqKey="Berendse H" first="Henk W." last="Berendse">Henk W. Berendse</name><name sortKey="Booij, Jan" sort="Booij, Jan" uniqKey="Booij J" first="Jan" last="Booij">Jan Booij</name><name sortKey="Stoffers, Diederick" sort="Stoffers, Diederick" uniqKey="Stoffers D" first="Diederick" last="Stoffers">Diederick Stoffers</name><name sortKey="Stoffers, Diederick" sort="Stoffers, Diederick" uniqKey="Stoffers D" first="Diederick" last="Stoffers">Diederick Stoffers</name><name sortKey="Van Eck Mit, Berthe L F" sort="Van Eck Mit, Berthe L F" uniqKey="Van Eck Mit B" first="Berthe L. F." last="Van Eck-Smit">Berthe L. F. Van Eck-Smit</name><name sortKey="Wolters, Erik Ch" sort="Wolters, Erik Ch" uniqKey="Wolters E" first="Erik Ch." last="Wolters">Erik Ch. Wolters</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001622 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001622 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:2CFD60A7F4B38A6BC5CE517081EBCB0B056A68EB
|texte= Idiopathic hyposmia as a preclinical sign of Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |